| Buffalo Sabres vs. Tampa Bay Lightning | 10-25-2021
Monday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Detroit Red Wings | 11-6-2021
Saturday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Edmonton Oilers | 11-12-2021
Friday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Toronto Maple Leafs | 11-13-2021
Saturday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Calgary Flames | 11-18-2021
Thursday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| New York Rangers vs. Buffalo Sabres | 11-21-2021
Sunday
6:00 PM | Madison Square Garden in New York, NY | View Tickets |
| Buffalo Sabres vs. Columbus Blue Jackets | 11-22-2021
Monday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Boston Bruins | 11-24-2021
Wednesday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Montreal Canadiens | 11-26-2021
Friday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Seattle Kraken | 11-29-2021
Monday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Anaheim Ducks | 12-7-2021
Tuesday
7:30 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. New York Rangers | 12-10-2021
Friday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Washington Capitals | 12-11-2021
Saturday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Columbus Blue Jackets | 12-20-2021
Monday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Colorado Avalanche | 12-22-2021
Wednesday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. New York Islanders | 12-27-2021
Monday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. New Jersey Devils | 12-29-2021
Wednesday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| New York Islanders vs. Buffalo Sabres | 12-30-2021
Thursday
7:30 PM | UBS Arena in Elmont, NY | View Tickets |
| Buffalo Sabres vs. San Jose Sharks | 1-6-2022
Thursday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Tampa Bay Lightning | 1-11-2022
Tuesday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Detroit Red Wings | 1-17-2022
Monday
1:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Dallas Stars | 1-20-2022
Thursday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Philadelphia Flyers | 1-22-2022
Saturday
1:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Minnesota Wild | 3-4-2022
Friday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Los Angeles Kings | 3-6-2022
Sunday
1:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Florida Panthers | 3-7-2022
Monday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Vegas Golden Knights | 3-10-2022
Thursday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Pittsburgh Penguins | 3-23-2022
Wednesday
7:30 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Washington Capitals | 3-25-2022
Friday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| New York Rangers vs. Buffalo Sabres | 3-27-2022
Sunday
5:00 PM | Madison Square Garden in New York, NY | View Tickets |
| Buffalo Sabres vs. Winnipeg Jets | 3-30-2022
Wednesday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Nashville Predators | 4-1-2022
Friday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Florida Panthers | 4-3-2022
Sunday
1:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Carolina Hurricanes | 4-5-2022
Tuesday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. St. Louis Blues | 4-14-2022
Thursday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Philadelphia Flyers | 4-16-2022
Saturday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Ottawa Senators | 4-20-2022
Wednesday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
| New Jersey Devils vs. Buffalo Sabres | 4-21-2022
Thursday
7:00 PM | Prudential Center in Newark, NJ | View Tickets |
| Buffalo Sabres vs. New York Islanders | 4-23-2022
Saturday
12:30 PM | KeyBank Center in Buffalo, NY | View Tickets |
| Buffalo Sabres vs. Chicago Blackhawks | 4-29-2022
Friday
7:00 PM | KeyBank Center in Buffalo, NY | View Tickets |
